Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization, might provide remedy and enhance treatment responses. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments, or applications of interventions targeting only a single organ level. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases.
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